VOGT-KOYANAGI-HARADA (VKH) SYNDROME

It is an idiopathic multisystem disorder which includes
cutaneous, neurological and ocular lesions. The
disease is comparatively more common in Japanese
who are usually positive for HLA-DR4 and DW15.
Clinical features
1. Cutaneous lesions include: alopecia, poliosis and
vitiligo.
2. Neurological lesions are in the form of meningism,
encephalopathy, tinnitus, vertigo and deafness.
3. Ocular features are bilateral chronic granulomatous
anterior uveitis, posterior uveitis and
exudative retinal detachment.
Treatment. It comprises steroids administered
topically, periocularly and systemically.